Dry cough after testosterone undecanoate injection: a case report

Autores/as

  • Roberto Vita Department of Clinical and Experimental Medicine, University of Messina, Messina
  • Giovanni Capodicasa Department of Clinical and Experimental Medicine, University of Messina, Messina
  • Sarah Perelli Department of Clinical and Experimental Medicine, University of Messina, Messina
  • Salvatore Benvenga <p>Department of Clinical and Experimental Medicine, University of Messina, Messina.</p> <p>Master Program on Childhood, Adolescent and Women’s Endocrine Health, University of Messina, Messina.</p> <p>Interdepartmental Program of Molecular &amp; Clinical Endocrinology and Women’s Endocrine Health, University hospital, A.O.U. Policlinico G. Martino, Messina.</p>

DOI:

https://doi.org/10.6092/1828-6550/APMB.106.2.2018.A7

Palabras clave:

testosterone, cough, pulmonary oil microembolism, gender dysphoria

Resumen

Testosterone esters are administered in oil vehicle via the intramuscular route. Rarely, dry cough together with faintness, diaphoresis, anxiety and syncope caused by pulmonary oil microembolism(POME) may occur. POME events are generally self-limited and last a few minutes. Very rarely they need oxygen therapy. Pathophysiology is still unclear. Here we report a case of POME occurring shortly after injection of testosterone undecanoate. The patient, a transmen on cross-gender hormonal treatment, was worried for the possible withdrawal of testosterone therapy. We reassured him and explained that he could continue his treatment provided that testosterone injections should be kept properly administered

Referencias

1. Bhasin, S., Brito, J.P., Cunningham, G.R., Hayes, F.J., Hodis, H.N., Matsumoto, A.M., Snyder, P.J., Swerdloff, R.S., Wu, F.C., Yialamas, M.A. (2018). Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline. J ClinEndocrinolMetab, 103(5),1715-1744. doi: 10.1210/jc.2018-00229.

2. Hembree, W.C., Cohen-Kettenis, P.T., Gooren, L., Hannema, S.E., Meyer, W.J., Murad, M.H., Rosenthal, S.M., Safer, J.D., Tangpricha, V., T'Sjoen, G.G. (2017). Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline. J ClinEndocrinolMetab, 102(11), 3869-3903. doi: 10.1210/jc.2017-01658.

3. Meyer, R.J., Mann, M. (2015). Pulmonary oil micro-embolism (POME) syndrome: a review and summary of a large case series. Curr Med Res Opin, 31(4), 837-841. doi: 10.1185/03007995.2015.1012254.

4.Middleton, T., Turner, L., Fennell. C., Savkovic, S., Jayadev, V., Conway, A.J., Handelsman, D.J. (2015). Complications of injectable testosterone undecanoate in routine clinical practice. Eur J Endocrinol, 172(5), 511-517. doi: 10.1530/EJE-14-0891.

5.Russell, M., Storck, A., Ainslie, M. (2011). Acute respiratory distress following intravenous injection of an oil-steroid solution. Can Respir J, 18(4), e59. doi: 10.1155/2011/743151.

6.Mackey, M.A., Conway, A.J., Handelsman, D.J. (1995). Tolerability of intramuscular injections of testosterone ester in oil vehicle. Hum Reprod, 10(4), 862-865.

Gu, Y., Liang, X., Wu, W., Liu, M., Song, S., Cheng, L., Bo, L., Xiong, C., Wang, X., Liu, X., Peng, L., Yao, K. (2009). Multicenter contraceptive efficacy trial of injectable testosterone undecanoate in Chinese men. J ClinEndocrinolMetab, 94(6),1910-1915. doi: 10.1210/jc.2008-1846

Descargas

Publicado

2018-12-18

Número

Vol. 106 Núm. 2 (2018)

Sección

CLINICAL CASE SEMINAR

Licencia

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:
  • Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  • Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  • Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).