Unusual sellar lesions mimicking a pituitary neuroendocrine tumour (PitNET)

Autores/as

  • Cristina Pizzimenti Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina
  • Mariausilia Franchina Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, Section of Anatomic Pathology, University of Messina
  • Vincenzo Fiorentino Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, Section of Anatomic Pathology, University of Messina
  • Salvatore Cannavò Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, Section of Endocrinology, University of Messina
  • Francesco Ferraù Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, Section of Endocrinology, University of Messina
  • Antonio Ieni Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, Section of Anatomic Pathology, University of Messina
  • Guido Fadda Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, Section of Anatomic Pathology, University of Messina
  • Giovanni Tuccari

DOI:

https://doi.org/10.13129/1828-6550/APMB.110.2.2022.CCS2

Palabras clave:

PitNET, sellar lesions, hypophysitis, meningioma

Resumen

Sellar region hosts a wide range of different types of lesions. Most of these lesions present with mass effect symptoms and, often, with symptoms related to hormonal disturbances, mimicking a pituitary neuroendocrine tumour (PitNET). We report two cases of sellar lesions with clinical and radiological features suggestive for PitNET. Histological and immunohistochemical analysis led to a diagnosis respectively for lymphocytic hypophysitis (LH) and meningioma.

Referencias

1. Saeger, W., Lüdecke, D.K., Buchfelder, M., Fahlbusch, R., Quabbe, H.-J., Petersenn, S. (2007). Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry. Eur J Endocrinol, 156(2):203–16. doi: 10.1530/eje.1.02326.

2. Lloyd, R.V., Osamura, R.Y., Kloppel, G. (2017). WHO classification of tumours of endocrine organs. 4th ed. Lyon: International Agency for Research on Cancer (IARC).

3. Bresson, D., Herman, P., Polivka, M., Froelich, S. (2016). Sellar Lesions/Pathology. Otolaryngol Clin North Am, 49(1):63–93. doi: http://dx.doi.org/10.1016/j.otc.2015.09.004.

4. Thakkar, K., Ramteke-Jadhav, S., Kasaliwal, R., et al. (2020). Sellar surprises: A single-centre experience of unusual sellar masses. Endocr Connect, 9(2):111–21. doi: 10.1530/EC-19-0497.

5. Freda, P.U., Post, K.D. (1999). Differential diagnosis of sellar masses. Endocrinol Metab Clin North Am, 28(1):81–117. doi: 10.1016/s0889-8529(05)70058-x.

6. Fatemi, N., Dusick, J.R., de Paiva Neto, M.A., Kelly, D.F. (2008). The endonasal microscopic approach for pituitary adenomas and other parasellar tumors. Oper Neurosurg, 63(4):244–56. doi: 10.1227/01.NEU.0000327025.03975.BA.

7. Joshi, M.N., Whitelaw, B.C., Carroll, P.V. (2018). Hypophysitis : diagnosis and treatment. Eur J Endocrinol., 179(3):R151-R163. doi:10.1530/EJE-17-0009.

8. Langlois, F., Varlamov, E.V., Fleseriu, M. (2022). Hypophysitis, the Growing Spectrum of a Rare Pituitary Disease. J Clin Endocrinol Metab, 107(1):10–28. doi:10.1210/clinem/dgab672.

9. Louis, D.N., Perry, A., Wesseling, P., et al. (2021) The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol, 23(8):1231–51. doi:10.1093/neuonc/noab106.

Zada, G., Lopes, M.B., Mukundan, S., Laws, E. (2016). Atlas of Sellar and Parasellar Lesions, Springer, doi:10.1007/978-3-319-22855-6

Descargas

Publicado

2022-12-22

Número

Sección

CLINICAL CASE SEMINAR