Brown tumors: an uncommon manifestation of bone disease in primary hyperparathyroidism

Authors

  • Giuseppe Giuffrida Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Messina
  • Rosaria M. Ruggeri Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Messina
  • Alfredo Campennì Unit of Nuclear Medicine, Department of Biomedical and Dental Sciences and Morpho-Functional Images, University of Messina
  • Teresa Malara Orthopaedics and Traumatology Section, Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, University of Messina
  • Salvatore Giovinazzo Department of Human Pathology of Adulthood and Childhood “G. Barresi”, University of Messina
  • Rosaria Certo Department of Human Pathology of Adulthood and Childhood “G. Barresi”, University of Messina
  • Francesco Trimarchi Accademia Peloritana dei Pericolanti at the University of Messina, Messina
  • Salvatore Cannavò Department of Human Pathology of Adulthood and Childhood “G. Barresi”, University of Messina
  • Michele A. La Rosa Accademia Peloritana dei Pericolanti at the University of Messina, Messina

DOI:

https://doi.org/10.6092/1828-6550/APMB.107.1.2019.CCS3

Keywords:

osteitis fibrosa cystica, brown tumor, primary hyperparathyroidism, parathyroidectomy, hungry bone syndrome

Abstract

Bone involvement in primary hyperparathyroidism (PHPT) is characterized by decreased bone mineral density, bone resorption at both trabecular and cortical sites and bone erosions, up to brown tumors (BT) and cysts, the so-called osteitis fibrosa cystica (OFC). Signs and symptoms of OFC include bone pain, muscle weakness, skeletal deformities and pathological fractures. In recent years, PHPT has greatly changed its clinical expression, especially in Western countries. For these reason BT, a typical expression of OFC, are always less observed and often mistaken for malignancy. An integrated diagnostic approach, considering first a complete biochemical panel and a confirmation by functional imaging, is crucial for a correct diagnosis, mostly considering that such skeletal manifestations may be reversible after surgical cure of PHPT.

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Published

2019-04-18

Issue

Vol. 107 No. 1 (2019)

Section

CLINICAL CASE SEMINAR

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