Aortic stiffness in older persons, determinants and consequences
DOI:
https://doi.org/10.6092/1828-6550/APMB.108.1.2020.SD3Parole chiave:
Arterial stiffnees, older adults, arteriosclerosisAbstract
Vascular aging is an age-related process characterized by stiffening of the arteries, a process which is accelerated by cardiovascular risk factors such as hypertension and diabetes mellitus.
Arterial stiffness can deeply influence short- and long-term blood pressure profiles, influences the patterns of hypertension in older subjects and increases the risk of primary and secondary cardiovascular events. Also, arterial stiffness, seems to play a role in determining functional and cognitive decline in older age.
Riferimenti bibliografici
1. Mukherje, D.P.,Kagan, H.M., Jordan, R.E., Franzblau C.(1976).Effect of hydrophobic elastin ligands on the stress-strain properties of elastin fibers. Connect Tissue Res.4(3),177-179.
2. Johnson, W.T., Salanga G., Lee W. et al.(1986). Arterial intimal embrittlement. A possible factor in atherogenesis. Atherosclerosis. 59(2), 161-171.
3. Kato, Y.P., Christiansen, D.L., Hahn, R.A., Shieh, S.J., Goldstein, J.D., Silver, F.H.(1989).Mechanical properties of collagen fibres: a comparison of reconstituted and rat tail tendon fibres. Biomaterials. 10(1), 38-42.
4. O'Rourke, M.F., Blazek, J.V., Morreels, C.L., Jr., Krovetz, LJ.(1968). Pressure wave transmission along the human aorta. Changes with age and in arterial degenerative disease. Circ Res. 23(4),567-579.
5. Buntin, C.M., Silver, F.H.(1990). Noninvasive assessment of mechanical properties of peripheral arteries. Ann Biomed Eng. 18(5), 549-566.
Avolio, A.P., Deng, F.Q., Li, W.Q., et al.(1985). Effects of aging on arterial distensibility in populations with high and low prevalence of hypertension: comparison between urban and rural communities in China. Circulation. 71(2), 202-210.
6. Kelly, R., Hayward, C., Avolio, A., O'Rourke, M. (1989).Noninvasive determination of age-related changes in the human arterial pulse. Circulation. 80(6), 1652-1659.
7. Bogren, H.G., Mohiaddin, R.H., Klipstein, R.K., et al.(1989). The function of the aorta in ischemic heart disease: a magnetic resonance and angiographic study of aortic compliance and blood flow patterns. Am Heart J. 118(2), 234-247.
8. Ohtsuka, S., Kakihana, M., Watanabe, H., Sugishita, Y. (1994).Chronically decreased aortic distensibility causes deterioration of coronary perfusion during increased left ventricular contraction. J Am Coll Cardiol. 24(5), 1406-1414.
9. Franklin, S.S., Gustin, W.t., Wong, N.D., et al.(1997). Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study. Circulation. 96(1), 308-315.
10. Hofman, A., Grobbee, D.E., de Jong, P.T., van den Ouweland, F.A. (1991).Determinants of disease and disability in the elderly: the Rotterdam Elderly Study. Eur J Epidemiol. 7(4), 403-422.
11. Avolio, A.P., Chen, S.G., Wang, R.P., Zhang, C.L., Li, M.F., O'Rourke, M.F.(1983).Effects of aging on changing arterial compliance and left ventricular load in a northern Chinese urban community. Circulation. 68(1), 50-58.
12. Benetos, A., Laurent, S., Hoeks, A.P., Boutouyrie, P.H., Safar, M.E. (1993).Arterial alterations with aging and high blood pressure. A noninvasive study of carotid and femoral arteries. Arterioscler Thromb. 13(1), 90-97.
13. Safar, M.E., Laurent, S., Pannier, B.M,, London, G.M.(1987). Structural and functional modifications of peripheral large arteries in hypertensive patients. J Clin Hypertens. 3(3), 360-367.
14. Airaksinen, K.E., Salmela, P.I., Linnaluoto, M.K., Ikaheimo, M.J., Ahola, K., Ryhanen, L.J.(1993). Diminished arterial elasticity in diabetes: association with fluorescent advanced glycosylation end products in collagen. Cardiovasc Res. 27(6), 942-945.
15. Meng, J., Sakata, N., Takebayashi, S., et al.(1996). Advanced glycation end products of the Maillard reaction in aortic pepsin-insoluble and pepsin-soluble collagen from diabetic rats. Diabetes. 45(8), 1037-1043.
16. Dart, A.M., Lacombe, F., Yeoh, J.K., et al. (1991).Aortic distensibility in patients with isolated hypercholesterolaemia, coronary artery disease, or cardiac transplant. Lancet. 338(8762),270-273.
17. Giannattasio, C., Mangoni, A.A., Failla, M., et al.(1996). Impaired radial artery compliance in normotensive subjects with familial hypercholesterolemia. Atherosclerosis. 124(2),249-260.
18. Kupari, M., Hekali, P., Keto, P., Poutanen, V.P., Tikkanen, M.J., Standerstkjold-Nordenstam, C.G.(1994). Relation of aortic stiffness to factors modifying the risk of atherosclerosis in healthy people. Arterioscler Thromb. 14(3), 386-394.
19. Mattace-Raso, F.U., van der Cammen, T.J., van der Meer,I.M., et al.(2004). C-reactive protein and arterial stiffness in older adults: the Rotterdam Study. Atherosclerosis. 176(1), 111-116.
20. Ross, R.(1999). Atherosclerosis-an inflammatory disease. N Engl J Med. 340(2), 115-126.
van der Meer, I.M., de Maat, M.P., Bots, M.L., et al.(2002). Inflammatory mediators and cell adhesion molecules as indicators of severity of atherosclerosis: the Rotterdam Study. Arterioscler Thromb Vasc Biol. 22(5), 838-842.
21. Ridker, P.M., Cushman, M., Stampfer, M.J., Tracy, R.P., Hennekens, C.H.(1997). Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med. 336(14),973-979.
22. Ridker, P.M., Rifai, N., Stampfer, M.J., Hennekens, C.H.(2000). Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation. 101(15), 1767-1772.
23. Koenig, W., Sund, M., Frohlich, M., et al.(1999). C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease). Augsburg Cohort Study, 1984 to 1992. Circulation. 99(2), 237-242.
24. Van der Meer, I.M, de Maat, M.P., Kiliaan, A.J., van der Kuip, D.A., Hofman, A., Witteman,J.C.(2003). The value of C-reactive protein in cardiovascular risk prediction: the Rotterdam Study. Arch Intern Med. 163(11), 1323-1328.
25. Abramson, J.L., Weintraub, W.S., Vaccarino, V.(2002). Association between pulse pressure and C-reactive protein among apparently healthy US adults. Hypertension. 39(2), 197-202.
26. Yudkin, J.S., Stehouwer, C.D., Emeis, J.J., Coppack, S.W. (1999).C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol. 19(4), 972-978.
27. Pradhan, A .D., Manson, J.E., Rifa,i N., Buring, J.E., Ridker, P.M.(2001). C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. Jama. 286(3), 327-334.
28. Thorand, B., Lowel, H., Schneider, A., et al. (2003).C-reactive protein as a predictor for incident diabetes mellitus among middle-aged men: results from the MONICA Augsburg cohort study, 1984-1998. Arch Intern Med. 163(1), 93-99.
29. Chae, C.U., Lee, R.T., Rifai, N., Ridker, P.M. (2001).Blood pressure and inflammation in apparently healthy men. Hypertension. 38(3), 399-403.
30. Fichtlscherer, S., Rosenberger,G., Walter, D.H., Breuer, S., Dimmeler, S., Zeiher, A.M.(2000). Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease. Circulation. 102(9), 1000-1006.
31. Vallance, P., Collier, J., Moncada, S.(1989). Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet. 2(8670), 997-1000.
32. Haynes, W.G., Noon J.P., Walker, B.R., Webb, D.J.(1993). Inhibition of nitric oxide synthesis increases blood pressure in healthy humans. J Hypertens. 11(12), 1375-1380.
33. I.B., Qasem, A., McEniery, C.M., Webb, D.J., Avolio, A.P., Cockcroft, J.R.(2002). Nitric oxide regulates local arterial distensibility in vivo. Circulation. 105(2), 213-217.
34. Ramsey, M.W., Goodfellow, J., Jones, C.J., Luddington, L.A., Lewis, M.J., Henderson, A.H. (1995). Endothelial control of arterial distensibility is impaired in chronic heart failure. Circulation. 92(11), 3212-3219.
35. Joannides, R., Richard, V., Haefel,W.E., et al.(1997). Role of nitric oxide in the regulation of the mechanical properties of peripheral conduit arteries in humans. Hypertension. 30(6), 1465-1470.
36. Arcaro, G., Laurent, S., Jondeau, G., Hoeks, A.P., Safar, M.E. (1991).Stiffness of the common carotid artery in treated hypertensive patients. J Hypertens. 9(10), 947-954.
37. Safar, M.E., Laurent, S., Benetos, A., London, G.M.(1988). The common carotid circulation in patients with essential hypertension. Stroke. 19(10), 1198-1202.
38. Asmar, R.G., Julia, P.L., Mascarel, V.L., Fabiani, J.N., Benetos, A., Safar, M.E. (1994). Ambulatory blood pressure profile after carotid endarterectomy in patients with ischaemic arterial disease. J Hypertens. 12(6),697-702.
39. Heiss, G., Sharrett, A.R., Barnes, R., Chambless, L.E., Szklo, M., Alzola, C.(1991). Carotid atherosclerosis measured by B-mode ultrasound in populations: associations with cardiovascular risk factors in the ARIC study. Am J Epidemiol. 134(3), 250-256.
40. Amar, J., Ruidavets, J.B., Chamontin, B., Drouet, L., Ferrieres, J. (2001).Arterial stiffness and cardiovascular risk factors in a population-based study. J Hypertens. 19(3), 381-387.
van Popele, N.M., Grobbee, D.E., Bots, M.L., et al. (2001).Association between arterial stiffness and atherosclerosis: the Rotterdam Study. Stroke. 32(2), 454-460.
41. Farrar, D.J., Bond, M.G., Sawyer, J.K., Green, H.D.(1984). Pulse wave velocity and morphological changes associated with early atherosclerosis progression in the aortas of cynomolgus monkeys. Cardiovasc Res. 18(2), 107-118.
42. Megnien, J.L., Simon, A., Denarie, N., et al.(1998). Aortic stiffening does not predict coronary and extracoronary atherosclerosis in asymptomatic men at risk for cardiovascular disease. Am J Hypertens. 11(3 Pt 1), 293-301.
43. Oren, A., Vos, L.E., Uiterwaal, C.S., Grobbee, D.E., Bots, M.L. (2003).Aortic stiffness and carotid intima-media thickness: two independent markers of subclinical vascular damage in young adults? Eur J Clin Invest. 33(11), 949-954.
44. Laurent,S., Boutouyrie, P., Lacolley, P.(2005). Structural and genetic bases of arterial stiffness. Hypertension. 45(6), 1050-1055.
45. Lacolley, P., Challande, P., Osborne-Pellegrin, M., Regnault, V.(2008). Genetics and pathophysiology of arterial stiffness. Cardiovascular research. 81(4),637-648.
46. Johnston, C.I. (1994).Tissue angiotensin converting enzyme in cardiac and vascular hypertrophy, repair, and remodeling. Hypertension. 23(2), 258-268.
47. Morishita, R., Gibbons, GH., Ellison, K.E., et al. (1994).Evidence for direct local effect of angiotensin in vascular hypertrophy. In vivo gene transfer of angiotensin converting enzyme. J Clin Invest. 94(3), 978-984.
48. Cambien, F., Poirier, O., Lecerf, L., et al. (1992).Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature. 359(6396), 641-644.
49. Samani, N.J., Thompson, J.R., O'Toole, L., Channer, K., Woods, K.L. (1996).A meta-analysis of the association of the deletion allele of the angiotensin-converting enzyme gene with myocardial infarction. Circulation. 94(4), 708-712.
50. Carluccio, M., Soccio, M., De Caterina, R.(2001). Aspects of gene polymorphisms in cardiovascular disease: the renin-angiotensin system. Eur J Clin Invest. 31(6), 476-488.
51. Sayed-Tabatabaei,F.A., Houwing-Duistermaat, J.J., van Duijn, C.M., Witteman, J.C. (2003).Angiotensin-converting enzyme gene polymorphism and carotid artery wall thickness: a meta-analysis. Stroke. 34(7), 1634-1639.
52. Benetos, A., Gautier, S., Ricard, S., et al.(1996). Influence of angiotensin-converting enzyme and angiotensin II type 1 receptor gene polymorphisms on aortic stiffness in normotensive and hypertensive patients. Circulation. 94(4), 698-703.
53. Taniwaki, H., Kawagishi, T., Emoto, M., et al. (1999).Association of ACE gene polymorphism with arterial stiffness in patients with type 2 diabetes. Diabetes Care. 22(11), 1858-1864.
54. Balkestein, E.J., Staessen, J.A., Wang, J.G., et al. (2001).Carotid and femoral artery stiffness in relation to three candidate genes in a white population. Hypertension. 38(5), 1190-1197.
55. Rigat, B., Hubert, C., Alhenc-Gelas, F., Cambien, F., Corvol, P., Soubrier, F. (1990).An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 86(4), 1343-1346.
56. Tiret, L., Rigat, B., Visvikis, S., et al.(1992). Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet. 51(1), 197-205.
57. Danser, A.H., Schalekamp, M.A., Bax, W.A, et al.(1995). Angiotensin-converting enzyme in the human heart. Effect of the deletion/insertion polymorphism. Circulation. 92(6), 1387-1388.
58. Daemen, M.J., Lombardi, D.M., Bosman, F.T., Schwartz, S.M.(1991). Angiotensin II induces smooth muscle cell proliferation in the normal and injured rat arterial wall. Circ Res. 68(2), 450-456.
59. Kato, H., Suzuki, H., Tajima, S., et al.(1991). Angiotensin II stimulates collagen synthesis in cultured vascular smooth muscle cells. J Hypertens. 9(1), 17-22.
60. Powell, J.S., Clozel, J.P, Muller, R.K., et al.(1989). Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury. Science. 245(4914), 186-188.
Farhy, R.D., Ho, K.L., Carretero, O.A., Scicli, A.G.(1992). Kinins mediate the antiproliferative effect of ramipril in rat carotid artery. Biochem Biophys Res Commun. 182(1), 283-288.
61. Benetos, A., Okuda,K., Lajemi, M., et al.(2001). Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity. Hypertension. 37(2 Part 2), 381-385.
62. Hanon, O., Luong, V., Mourad, J.J., Bortolotto, L.A,, Jeunemaitre, X., Girerd, X. (2001).Aging, carotid artery distensibility, and the Ser422Gly elastin gene polymorphism in humans. Hypertension. 38(5), 1185-1189.
63. Brull, D.J., Murray, L.J., Boreham, C.A., et al. (2001).Effect of a COL1A1 Sp1 binding site polymorphism on arterial pulse wave velocity: an index of compliance. Hypertension. 38(3),444-448.
64. Levy, D., Larson, M.G., Benjamin, E.J., et al.(2007). Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. BMC Med Genet. 8 Suppl 1:S3.
65. McVeigh, G.E., Morgan, D.J., Finkelstein, S.M., Lemay, L.A., Cohn, J.N. (1997).Vascular abnormalities associated with long-term cigarette smoking identified by arterial waveform analysis. Am J Med. 102(3), 227-231.
66. Kool, M.J., Hoeks, A.P., Struijker, Boudier, H.A., Reneman, R.S., Van Bortel, L.M. (1993).Short- and long-term effects of smoking on arterial wall properties in habitual smokers. J Am Coll Cardiol. 22(7),1881-1886.
67. Vaitkevicius, P.V., Fleg, J.L., Engel, J.H., et al.(1993). Effects of age and aerobic capacity on arterial stiffness in healthy adults. Circulation. 88(4 Pt 1), 1456-1462.
68. Friedman, L.,A., Kimball, A.W.(1986). Coronary heart disease mortality and alcohol consumption in Framingham. Am J Epidemiol. 124(3), 481-489.
69. Doll, R., Peto, R., Hall, E., Wheatley, K., Gray, R.(1994). Mortality in relation to consumption of alcohol: 13 years' observations on male British doctors. Bmj. 309(6959), 911-918.
70. Gaziano, J.M., Gaziano, T.A., Glynn, R.J., et al.(2000). Light-to-moderate alcohol consumption and mortality in the Physicians' Health Study enrollment cohort. J Am Coll Cardiol. 35(1), 96-105.
71. Nakanishi, N., Kawashimo, H., Nakamura, K., et al.(2001). Association of alcohol consumption with increase in aortic stiffness: a 9-year longitudinal study in middle-aged Japanese men. Ind Health. 39(1), 24-28.
72. Namekata, T., Moore, D., Suzuki, K., et al. (1997).[A study of the association between the aortic pulse wave velocity and atherosclerotic risk factors among Japanese Americans in Seattle, U.S.A.]. Nippon Koshu Eisei Zasshi. 44(12), 942-951.
73. Sierksma, A., Lebrun, C.E., van der Schouw, Y.T., et al. (2004).Alcohol consumption in relation to aortic stiffness and aortic wave reflections: a cross-sectional study in healthy postmenopausal women. Arterioscler Thromb Vasc Biol. 24(2), 342-348.
74. Mattace-Raso, F.U., van der Cammen, T.J., van den Elzen, A.P., et al. (2005).Moderate alcohol consumption is associated with reduced arterial stiffness in older adults: the Rotterdam study. J Gerontol A Biol Sci Med Sci. 60(11), 1479-1483.
75. Roman, M.J., Saba, P.S., Pini, R., et al. (1992).Parallel cardiac and vascular adaptation in hypertension. Circulation. 86(6), 1909-1918.
76. Girerd, X., Mourad, J.J., Copie, X., et al. (1994).Noninvasive detection of an increased vascular mass in untreated hypertensive patients. Am J Hypertens. 7(12), 1076-1084.
77. Wada, T., Kodaira, K., Fujishiro, K., et al.(1994). Correlation of ultrasound-measured common carotid artery stiffness with pathological findings. Arterioscler Thromb. 14(3), 479-482.
78. Laurent, S., Boutouyrie, P., Asmar, R., et al. (2001).Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension. 37(5), 1236-1241.
79. Boutouyrie, P., Tropeano, AI., Asmar, R., et al.(2002). Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study. Hypertension. 39(1),10-15.
80. Laurent, S., Katsahian, S., Fassot, C., et al.(2003). Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke. 34(5), 1203-1206.
81. Blacher, J., Guerin, A.P., Pannier, B., Marchais, S.J., Safar, M.E., London, G.M.(1999). Impact of aortic stiffness on survival in end-stage renal disease. Circulation. 99(18), 2434-2439.
82. Blacher, J., Safar, M.E., Guerin, A.P., Pannier, B., Marchais, S.J., London, G.M.(2003). Aortic pulse wave velocity index and mortality in end-stage renal disease. Kidney Int. 63(5), 1852-1860.
83. Adji, A., O'Rourke, M.F., Namasivayam, M. (2011).Arterial Stiffness, Its Assessment, Prognostic Value, and Implications for Treatment. American Journal of Hypertension. 24(1), 5-17.
84. Vlachopoulos, C., Aznaouridis, K., Stefanadis, C. (2010).Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. Journal of the American College of Cardiology. 55(13), 1318-1327.
85. Kim, E.D., Ballew, S.H., Tanaka, H., Heiss, G., Coresh, J., Matsushita, K. (2019).Short-Term Prognostic Impact of Arterial Stiffness in Older Adults Without Prevalent Cardiovascular Disease. Hypertension. 74(6), 1373-1382.
86. Mattace-Raso, F.U., van der Cammen, T.J., Hofman, A., et al.(2006). Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation. 113(5), 657-663.
87. Criqui, M.H., Langer, R.D., Fronek, A., et al. (1992).Mortality over a period of 10 years in patients with peripheral arterial disease. N Engl J Med. 326(6), 381-386.
88. Newman, A.B., Shemanski, L., Manolio, T.A., et al.(1999). Ankle-arm index as a predictor of cardiovascular disease and mortality in the Cardiovascular Health Study. The Cardiovascular Health Study Group. Arterioscler Thromb Vasc Biol. 19(3), 538-545.
Van der Meer, I.M., Bots, M.L., Hofman, A., del Sol AI, van der Kuip, D.A., Witteman, J.C. (2004).Predictive value of noninvasive measures of atherosclerosis for incident myocardial infarction: the Rotterdam Study. Circulation. 109(9), 1089-1094.
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