Diagnosis of Growth Hormone Deficiency in Childhood: Progress Report

Autori

  • Tommaso Aversa <p>Department of Human Pathology in Adulthood and Childhood “G. Barresi”, University of Messina<strong><br /></strong></p>
  • Filippo De Luca Department of Human Pathology in Adulthood and Childhood “G. Barresi”, University of Messina

DOI:

https://doi.org/10.6092/1828-6550/APMB.106.2.2018.SD1

Parole chiave:

Growth Hormone Deficiency, Growth Hormone stimulation tests, Neuroimaging, Short stature

Abstract

Growth hormone (GH) deficiency (GHD) is a rare condition with a prevalence of approximately 1 in 4000 during childhood. GHD may be either congenital or acquired. The diagnosis of GHD can be difficult, particularly in idiopathic isolated GHD. There are significant controversies in the diagnosis of GHD in childhood. GH stimulation tests are the key factors in GHD diagnosis, but these tests are poorly reproducible and serum GH concentration measurements can vary significantly according to stimulation tests and GH assays. Close to GH stimulation tests, other biochemical marker, such as IGF-I are useful, together with neuroimaging and genetic tests. These clinical, biochemical and radiological diagnostic tools, including their limits, are discussed in this review

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Pubblicato

2018-12-18

Fascicolo

V. 106 N. 2 (2018)

Sezione

SCHOLARLY DIALOGS

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