Immunohistochemical evidence of Aquaporin 1 (AQP1) in Fluoroedenite-induced mesotheliomas: a preliminary report

Autores/as

  • Giuseppe Angelico Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", Section of Anatomic Pathology, University of Messina, Messina
  • Antonio Ieni Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", Section of Anatomic Pathology, University of Messina, Messina
  • Caltabiano Rosario Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, "Policlinico-Vittorio Emanuele", Anatomic Pathology Section, University of Catania, Catania
  • Saveria Spadola Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, "Policlinico-Vittorio Emanuele", Anatomic Pathology Section, University of Catania, Catania
  • Giuseppe Giuffrè Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", Section of Anatomic Pathology, University of Messina, Messina
  • Giovanni Tuccari Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", Section of Anatomic Pathology, University of Messina, Messina

DOI:

https://doi.org/10.6092/1828-6550/APMB.105.1.2017.A10

Palabras clave:

Aquaporin 1, Malignant pleural, mesothelioma, fluoroedenite, immunohistochemistry, prognosis

Resumen

Malignant pleural mesothelioma (MPM) is a malignant tumour of the serosal membranes lining the pleural cavity, which has been linked with the occupational exposure to asbestos fibres; however, it rarely occurs in individuals not exposed to these fibres. In this regard, fluoroedenite (FE) fibres have been linked to increased mortality from pleural mesothelioma in Biancavilla, a town of eastern Sicily (Italy). These fibres are similar in size and morphology to amphibolic asbestos fibres and have been used as a building material for road paving and buildings in the town of Biancavilla and countries nearby. The aim of the present study was to investigate the immunohistochemical expression of Aquaporin 1 (AQP1) in a cohort of patients affected by MPM; taking into consideration its suggested independent prognostic role in asbestos related MPM, the possible correlation with clinicopathological parameters and patients outcomes was also evaluated.

Referencias

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Publicado

2017-06-30

Número

Vol. 105 Núm. 1 (2017)

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ARTICLES

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