Thermodynamics and SARS-CoV-2: neurological effects in post-Covid 19 syndrome

Authors

  • Umberto Lucia Politecnico di Torino
  • Giulia Grisolia Politecnico di Torino
  • Thomas S. Deisboeck Massachusetts General Hospital and Harvard Medical School

DOI:

https://doi.org/10.1478/AAPP.992A3

Keywords:

Irreversible thermodynamics, Membrane potential, Neurological effects, Post-Covid Syndrome, SARS-CoV-2.

Abstract

There is increasing evidence that infection with SARS-CoV-2 can cause a spectrum of neurological symptoms. In this paper, we develop a theoretical concept underlying such neurological COVID-19 consequences by employing a non-equilibrium thermodynamic approach that allows linking the neuronal electric potential with a virus-induced pH variation. Our theoretical findings support further experimental work on therapeutically correcting electrolyte imbalances, such as Na+ and K+, to attenuate the neurological effects of SARS-CoV-2.

Author Biographies

  • Umberto Lucia, Politecnico di Torino
    Dipartimento Energia "Galileo Ferraris", Corso Duca degli Abruzzi 24, 10129 Torino
  • Giulia Grisolia, Politecnico di Torino
    Dipartimento Energia "Galileo Ferraris", Corso Duca degli Abruzzi 24, 10129 Torino
  • Thomas S. Deisboeck, Massachusetts General Hospital and Harvard Medical School
    Department of Radiology, Harvard-MIT Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA

Downloads

Published

2021-10-27

Issue

Section

Articles