Production of 68Ge, 64Cu, 86Y, 89Zr, 73Se, 77Br and 124I positron emitting radionuclides through future laser-accelerated proton beams at ELI-Beamlines for innovative PET diagnostics

Authors

  • Antonio Italiano Istituto Nazionale di Fisica Nucleare
  • Ernesto Amato Università degli Studi di Messina
  • Fabio Minutoli Università degli Studi di Messina
  • Daniele Margarone Institute of Physics ASCR, v.v.i. (FZU)
  • Sergio Baldari Università degli Studi di Messina

DOI:

https://doi.org/10.1478/AAPP.942A2

Keywords:

Positron Emission Tomography, plasma laser, nuclear reactions

Abstract

The development of innovative production pathways for high-Z positron emitters is of great interest to enlarge the applicability of PET diagnostics, especially in view of the continuous development of new radiopharmaceuticals. We evaluated the theoretical yields of 64Cu, 86Y, 89Zr, 73Se, 77Br and 124I PET isotopes, plus the 68Ge isotope, parent of the 68Ga positron emitter, in the hypothesis of production through laser-accelerated proton sources expected at the ELI-Beamlines facility. By means of the TALYS software we simulated the nuclear reactions leading to the above radionuclides, hypothesizing three possible scenarios of broad proton spectra, with maximum energies of about 9, 40 and 100 MeV. The production yields of the studied radionuclides, within the expected fluences, appear to be suitable for pre-clinical applications.

Author Biographies

  • Antonio Italiano, Istituto Nazionale di Fisica Nucleare
    Gruppo Collegato di Messina
  • Ernesto Amato, Università degli Studi di Messina
    Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali
  • Fabio Minutoli, Università degli Studi di Messina
    Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali
  • Daniele Margarone, Institute of Physics ASCR, v.v.i. (FZU)
    ELI-Beamlines Project, 182 21 Prague
  • Sergio Baldari, Università degli Studi di Messina
    Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali

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Published

2016-05-18

Issue

Vol. 94 No. 2 (2016)

Section

Articles

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