Mathematical Models of Open and Closed Biochemical Reactions in Living Cells

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  • Alberto Maria Bersani
  • Morten Gram Pedersen
  • Enrico Bersani

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https://doi.org/10.1685/

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Cells transduce the external information by complex intracellular networks in which various layers and cascades can be identified. Mathematical models have been performed for some of these substructures, for example the MAPK cascade. For many respects this modelling is inadequate and needs new formal schemes. Here we apply a recently proposed scheme, in which each layer can be thought as a separate reaction, in which the upstream reactions can be represented by an input function M22_BersaniPedersenBersani0.png (on the concentrations of the substrate or of the enzyme catalyzing the reaction) explicitly introduced in the differential equations describing the reaction. On this scheme the total Quasi-Steady State Approximation (tQSSA) will be applied. [DOI: 10.1685/CSC06019] About DOI

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2007-10-01

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##issue.vol## 1 (2006)

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Articles

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